Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer
The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
Authors
- Martin Schønemann‐Lund (ORCID: https://orcid.org/0000-0001-5116-509X)
- Hanna Dahlstrand (ORCID: https://orcid.org/0000-0002-6166-3532)
- Line Bjørge (ORCID: https://orcid.org/0000-0002-0240-2770)
- Anne Krejbjerg (ORCID: https://orcid.org/0000-0002-9176-5599)
- Charlotte Aaquist Haslund (ORCID: https://orcid.org/0009-0004-6571-2196)
- Maria Rossing (ORCID: https://orcid.org/0000-0003-4325-3027)
- Theresa L. Werner (ORCID: https://orcid.org/0000-0003-3868-7795)
- Gitte-Bettina Nyvang (ORCID: https://orcid.org/0000-0001-5364-3497)
- Maj K. Kjeldsen (ORCID: https://orcid.org/0000-0001-5787-5412)
- Lars Fokdal (ORCID: https://orcid.org/0000-0003-4382-4694)
- Maarit Anttila (ORCID: https://orcid.org/0000-0001-6347-4180)
- Dina Sofie B. Grønseth (ORCID: https://orcid.org/0000-0002-5563-8197)
- Susanne Malander (ORCID: https://orcid.org/0000-0002-4059-1349)
- Trine Zeeberg Iversen
- Gabriel Lindahl (ORCID: https://orcid.org/0000-0001-9494-1765)
- Anja Ør Knudsen (ORCID: https://orcid.org/0009-0002-1871-3087)
- Mansoor Raza Mirza
- Sakari Hietanen (ORCID: https://orcid.org/0000-0003-4734-4743)
- Michael J. Birrer (ORCID: https://orcid.org/0000-0001-6464-4225)
- Maria Dimoula
- Johanna Mäenpää (ORCID: https://orcid.org/0000-0003-0486-6912)
- Morten Hulvej Jørgensen
Institutions
- Linköping University (SE)
- University of Copenhagen (DK)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- University of Southern Denmark (DK)
- Aalborg University Hospital (DK)
- Haukeland University Hospital (NO)
- Huntsman Cancer Institute (US)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Turku University Hospital (FI)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Nordic Society of Gynecologic Oncology (DK)
- Kuopio University Hospital (FI)
- Region of Southern Denmark (DK)
- Tampere University Hospital (FI)
- Winthrop Rockefeller Foundation (US)
- Tampere University (FI)
- Skåne University Hospital (SE)
- University of Bergen (NO)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0294
- Citations
- 4
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Rigshospitalet