Exploring the feasibility of using mice as a substitute model for investigating microglia in aging and Alzheimer’s disease though single cell analysis
Mouse Apoe and Cell_Apoe maybe serve as proxies for studying human AD, while Cx3cr1 and Cell_Cx3cr1 are suitable for human aging studies. However, AD mouse models (App_NL_G_F) have limitations in studying human genes like IL1RAPL1 and SPP1 related to AD. Thus, mouse models cannot fully replace human samples for AD and aging research.
Authors
- 融生 曽和 (ORCID: https://orcid.org/0000-0002-3850-5704)
- Dingyun You (ORCID: https://orcid.org/0000-0002-3830-1891)
- Yiwen Hu (ORCID: https://orcid.org/0000-0003-0072-0916)
- Qiang Zhang (ORCID: https://orcid.org/0000-0001-5641-8279)
- Limei Wang (ORCID: https://orcid.org/0000-0002-5041-2287)
- Yue Qiu (ORCID: https://orcid.org/0000-0002-9132-710X)
- Jishuai Cheng (ORCID: https://orcid.org/0000-0003-0769-858X)
- Jia Liu (ORCID: https://orcid.org/0000-0002-9771-192X)
Institutions
- Central South University (CN)
- Kunming Medical University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1371/journal.pone.0311374
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Kunming Medical University
- Applied Basic Research Foundation of Yunnan Province