Neonatal inflammation and near-term white matter microstructure in infants born very preterm
VPT infants with severe neonatal inflammation had lower FA in multiple white matter tracts, suggesting that inflammation-related alterations in WM development begin in the neonatal period. The observed differences detected using dMRI at term-equivalent age corroborate prior findings and may provide a window of opportunity for early identification of VPT infants at increased risk of poor neurodevelopmental outcomes.
Authors
- Melissa Scala (ORCID: https://orcid.org/0000-0002-5120-8077)
- Lisa Bruckert (ORCID: https://orcid.org/0000-0002-3472-3675)
- Virginia A. Marchman (ORCID: https://orcid.org/0000-0001-7183-6743)
- Molly F. Lazarus (ORCID: https://orcid.org/0009-0000-7839-073X)
- Katherine E. Travis (ORCID: https://orcid.org/0000-0002-0050-911X)
- Heidi M. Feldman (ORCID: https://orcid.org/0000-0002-4435-0913)
- Kathryn G. Anderson (ORCID: https://orcid.org/0000-0002-7046-1940)
- Rocío Velasco Poblaciones (ORCID: https://orcid.org/0000-0002-9177-8840)
Institutions
- Cornell University (US)
- Stanford University (US)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.ynirp.2024.100226
- Citations
- 4
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Stanford Maternal and Child Health Research Institute