IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity
Our research reveals IL-10RA as a pharmacological target in stromal cells for enhancing T cell-mediated PDAC eradication by downregulating IDO via blocked IL-10/IL-10RA signalling in MSCs. This advances IL-10RA interference in the tumour microenvironment (TME) to restore T cell cytotoxicity against cancers.
Authors
- Ching‐Yen Tsai (ORCID: https://orcid.org/0000-0001-7964-6661)
- Yu-Shao Yang
- Chien-Hui Wu (ORCID: https://orcid.org/0000-0002-6163-626X)
- Tzong-Shyuan Tai (ORCID: https://orcid.org/0000-0003-0575-914X)
- Jiaqi Shi (ORCID: https://orcid.org/0000-0002-8458-2364)
- Duen‐Wei Hsu (ORCID: https://orcid.org/0000-0001-5762-7806)
- Shu-Ching Hsu (ORCID: https://orcid.org/0000-0002-6244-2803)
Institutions
- National Kaohsiung Normal University (TW)
- Kaohsiung Medical University (TW)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- National Tsing Hua University (TW)
- Chang Gung Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
- Institute of Molecular Biology, Academia Sinica (TW)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1038/s41416-024-02893-3
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Shanghai Educational Development Foundation
- National Health Research Institutes
- National Science and Technology Council