First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial
First-line len + pembro did not meet prespecified statistical criteria for PFS or OS versus chemotherapy in pMMR aEC.
Authors
- I. V. Rykov (ORCID: https://orcid.org/0000-0002-8250-8144)
- Takuya Tsunoda (ORCID: https://orcid.org/0000-0002-6416-8211)
- Sally E. Baron-Hay (ORCID: https://orcid.org/0000-0002-9748-1458)
- Jianqing Zhu (ORCID: https://orcid.org/0000-0001-5736-7397)
- Graziela Zibetti Dal Molin (ORCID: https://orcid.org/0000-0002-8987-0066)
- João Paulo da Silveira Nogueira Lima (ORCID: https://orcid.org/0000-0001-7523-6964)
- Noriyuki Katsumata (ORCID: https://orcid.org/0000-0001-8863-5921)
- Xuemei Jia (ORCID: https://orcid.org/0000-0003-1762-4365)
- Tetiana Piatnytska
- N. E. Musaeva (ORCID: https://orcid.org/0000-0002-1999-0847)
- Alla Lisyanskaya (ORCID: https://orcid.org/0000-0002-4495-9681)
- Liliana Zamora
- A. Roszak (ORCID: https://orcid.org/0000-0002-7263-1261)
- Shuzhong Yao
- Christof Vulsteke (ORCID: https://orcid.org/0000-0002-4607-5660)
- Alessandro Davide Santin (ORCID: https://orcid.org/0000-0003-4724-9738)
- Hong Zheng (ORCID: https://orcid.org/0000-0002-0199-2940)
- Radoslav Chekerov (ORCID: https://orcid.org/0000-0001-9535-3033)
- Margarita Romeo (ORCID: https://orcid.org/0000-0003-1725-8115)
- Ricardo Villalobos-Valencia (ORCID: https://orcid.org/0000-0001-5669-7132)
- Anna Dańska-Bidzińska
- Suzanne Fortin
- Olena Sukhina (ORCID: https://orcid.org/0000-0002-1272-0764)
- Chinyere E. Okpara (ORCID: https://orcid.org/0000-0002-5621-9138)
- Lili Yao (ORCID: https://orcid.org/0009-0000-3963-5861)
- Aleksandr Vasiliev
- Masashi Takano (ORCID: https://orcid.org/0000-0001-6916-9398)
- Sufia Safina (ORCID: https://orcid.org/0000-0002-5309-8406)
- Marcia Hall (ORCID: https://orcid.org/0000-0003-0039-5041)
- Patricia Braly
- Yi Huang (ORCID: https://orcid.org/0000-0001-7273-8301)
- Álvaro Taus Garcia
- Tayup Şimşek (ORCID: https://orcid.org/0000-0003-1088-3970)
- Beata Maćkowiak-Matejczyk
- Claudio Zamagni (ORCID: https://orcid.org/0000-0003-0052-2581)
- Ignacio Casarini (ORCID: https://orcid.org/0000-0002-0479-9417)
- Saira Khalique (ORCID: https://orcid.org/0000-0001-8015-9764)
- Wiesława Bednarek (ORCID: https://orcid.org/0000-0001-8151-2697)
- Igor Bondarenko (ORCID: https://orcid.org/0000-0002-7071-2471)
- Ruffo Freitas‐Júnior (ORCID: https://orcid.org/0000-0003-4145-8598)
- Wataru Yamagami (ORCID: https://orcid.org/0000-0003-3925-6057)
- Marı́a Varela (ORCID: https://orcid.org/0000-0003-4288-2593)
- Paolo Scollo (ORCID: https://orcid.org/0000-0001-6275-7488)
- Michelle Harrison
- Emanuele Naglieri
- Margarita Sonia Alfie
- Kenzo Sonoda (ORCID: https://orcid.org/0000-0001-9887-3923)
- А. В. Белоногов
- Stephanie V. Blank (ORCID: https://orcid.org/0000-0002-5333-9484)
- Michael J. Friedlander (ORCID: https://orcid.org/0000-0003-3090-795X)
- Marlies De Bock (ORCID: https://orcid.org/0000-0001-9439-9881)
- Sang Wun Kim (ORCID: https://orcid.org/0000-0002-8342-8701)
- Jean‐François Baurain (ORCID: https://orcid.org/0000-0003-4876-4600)
- Yamil Alonso Lopez Chuken
- André P. L. Mattar (ORCID: https://orcid.org/0000-0001-5973-623X)
- А. А. Rumyantsev (ORCID: https://orcid.org/0000-0003-4443-9974)
- Catherine Shannon (ORCID: https://orcid.org/0000-0002-2078-2869)
- Stéphanie Lheureux (ORCID: https://orcid.org/0000-0003-4405-5890)
- Andréia Cristina de Melo (ORCID: https://orcid.org/0000-0002-1201-4333)
- F Marmé
- Fatih Köse (ORCID: https://orcid.org/0000-0002-0156-5973)
- Gonzalo Gómez Abuin
- А Ф Урманчеева
- Christian Marth (ORCID: https://orcid.org/0000-0002-8965-9981)
- Josée-Lyne Ethier (ORCID: https://orcid.org/0000-0003-0711-1021)
- Mario Beiner (ORCID: https://orcid.org/0000-0001-6392-8840)
- Nao Suzuki (ORCID: https://orcid.org/0000-0002-7440-8127)
- Susan Ellard (ORCID: https://orcid.org/0000-0001-5757-9787)
- Shin Nishio (ORCID: https://orcid.org/0000-0003-2526-630X)
- Ralf Witteler
- Deena M. Graham
- Bradley R. Corr (ORCID: https://orcid.org/0000-0002-6608-2585)
- Julia Fehniger
- Manuel Magallanes-Maciel (ORCID: https://orcid.org/0009-0002-4522-4545)
- Олександр Войтко (ORCID: https://orcid.org/0000-0002-4610-4476)
- Xiaohua Wu (ORCID: https://orcid.org/0000-0002-7664-8327)
- Stephan Polterauer (ORCID: https://orcid.org/0000-0002-9649-4505)
- Connie I. Diakos (ORCID: https://orcid.org/0000-0002-8877-3440)
- Jacob Korach (ORCID: https://orcid.org/0000-0003-0483-4582)
- Tomoka Usami (ORCID: https://orcid.org/0009-0004-5742-6421)
- Weiguo Lv
- Manuel Ernesto Magallanes Maciel
- Sharad Ghamande (ORCID: https://orcid.org/0000-0003-2242-2215)
- Sophia Frentzas (ORCID: https://orcid.org/0000-0002-6917-9737)
- Hung-Hsueh Chou
- Antonio Casado (ORCID: https://orcid.org/0000-0002-8200-3306)
- Helen J MacKay (ORCID: https://orcid.org/0000-0001-6220-1789)
- Robert Orlowski (ORCID: https://orcid.org/0000-0002-8037-9932)
- Tamara Díaz Redondo
- Richard G. Moore (ORCID: https://orcid.org/0000-0001-5598-5263)
- R. Tarnawski (ORCID: https://orcid.org/0000-0001-6802-5093)
- Anna Kryzhanivska (ORCID: https://orcid.org/0000-0001-7720-7374)
- Shoji Kamiura (ORCID: https://orcid.org/0000-0002-5723-8891)
- Mariusz Bidziński (ORCID: https://orcid.org/0000-0003-4767-6369)
- Hee Seung Kim (ORCID: https://orcid.org/0000-0001-6876-8671)
- Vivek Khemka
- А. Г. Кедрова (ORCID: https://orcid.org/0000-0003-1031-9376)
- Vanessa Samouëlian (ORCID: https://orcid.org/0000-0003-4409-147X)
- Chel Hun Choi (ORCID: https://orcid.org/0000-0002-0199-6669)
- Elena Ioana Braicu (ORCID: https://orcid.org/0000-0001-5357-6001)
- Gottfried E. Konecny (ORCID: https://orcid.org/0000-0001-6083-657X)
- João Daniel Guedes
- Regina Berger (ORCID: https://orcid.org/0000-0003-2952-6797)
- Michael Kolinsky (ORCID: https://orcid.org/0000-0002-3937-3782)
- Ali̇ Ayhan (ORCID: https://orcid.org/0000-0001-7155-9096)
- Alun David Hughes (ORCID: https://orcid.org/0000-0001-5432-5271)
- Paul Bessette (ORCID: https://orcid.org/0000-0002-4930-8503)
- Yoichi Kobayashi (ORCID: https://orcid.org/0000-0002-8474-0625)
- Koji Horie
- Mehmet Ali Vardar (ORCID: https://orcid.org/0000-0003-0616-6733)
- Lucy Gilbert (ORCID: https://orcid.org/0000-0001-8605-5472)
- Gina Westhoff
- Talia Levy
- Gemma Eminowicz (ORCID: https://orcid.org/0000-0001-6514-808X)
- Bo Gao (ORCID: https://orcid.org/0000-0002-7881-6603)
- Jodi A. McKenzie (ORCID: https://orcid.org/0000-0002-6345-1218)
- Wataru Kudaka (ORCID: https://orcid.org/0000-0002-7600-074X)
- Fábio Franke (ORCID: https://orcid.org/0000-0002-9417-2123)
- Tarek Meniawy (ORCID: https://orcid.org/0000-0002-1457-6137)
- Ewa Kalinka‐Warzocha (ORCID: https://orcid.org/0000-0003-4791-8372)
- Vicky Makker (ORCID: https://orcid.org/0000-0001-9793-7614)
- P. Koralewski
- Hidenori Kato (ORCID: https://orcid.org/0000-0002-2153-5843)
- Joseph Buscema
- Anna V. Tinker (ORCID: https://orcid.org/0000-0002-1190-7746)
- Sharyn N. Lewin
- Chien‐Hsing Lu (ORCID: https://orcid.org/0000-0001-7860-4320)
- Toon Van Gorp (ORCID: https://orcid.org/0000-0002-2564-721X)
- Paweł Mach (ORCID: https://orcid.org/0000-0002-7301-6746)
- Sandro Pignata (ORCID: https://orcid.org/0000-0002-8836-2633)
- Mayu Yunokawa (ORCID: https://orcid.org/0000-0001-7354-6977)
- Ignacio Romero Noguera
- María Jesús Rubio (ORCID: https://orcid.org/0000-0003-3682-3597)
- Yaroslav Kulyaba
- Kosei Hasegawa (ORCID: https://orcid.org/0000-0002-1903-7001)
- Lauren E. Bollinger
- Alison Stillie (ORCID: https://orcid.org/0000-0001-6635-6788)
- Ruifang An (ORCID: https://orcid.org/0000-0001-6501-1016)
- Akira Kikuchi (ORCID: https://orcid.org/0000-0003-3378-9522)
- Jennifer Scalici (ORCID: https://orcid.org/0000-0001-7895-4291)
- Diego Kaen
- RO de Sant'ana
- Fernanda Damian (ORCID: https://orcid.org/0000-0003-4651-3357)
- Edgar Petru (ORCID: https://orcid.org/0000-0001-8822-257X)
- Yulia Makarycheva
- Xiaojun Chen (ORCID: https://orcid.org/0000-0002-5493-1500)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-8456-7335)
- Francisco Cabrera (ORCID: https://orcid.org/0000-0002-6092-522X)
- Christine Lee (ORCID: https://orcid.org/0000-0002-3383-6360)
- Peng‐Hui Wang (ORCID: https://orcid.org/0000-0002-6048-8541)
- Qi Zhou (ORCID: https://orcid.org/0000-0001-5673-4263)
- Yumei Wu (ORCID: https://orcid.org/0000-0002-2242-9348)
- Yong Man Kim (ORCID: https://orcid.org/0000-0002-4222-3400)
- Nidhi Kumar Tyagi (ORCID: https://orcid.org/0000-0003-4017-2299)
- Vanda Salutari (ORCID: https://orcid.org/0000-0002-9420-7146)
- Kazuto Nakamura (ORCID: https://orcid.org/0000-0001-5738-3418)
- Sevilay Altıntaş
- Cailing Ma (ORCID: https://orcid.org/0000-0002-5807-8439)
- Kemal Özerkan (ORCID: https://orcid.org/0000-0003-1460-6524)
- Amnon Amit
- Charles Henry Lim
- Wen‐Fang Cheng (ORCID: https://orcid.org/0000-0002-3282-6304)
- Wu-Chou Lin
- Karen Cadoo
- Koji Matsumoto (ORCID: https://orcid.org/0000-0002-4425-9829)
- Maria C. Bell
- Jose Escobar Penagos
- Sumitra Ananda
- Charles E. Anderson
- M.J. Rubio Pérez
- V S Svintsitsky
- Linda Van Le
- Yong Beom Kim
- Lingya Pan
- R. Mendoza
- Hanna Averina
- Yuliia Krasnohrud
- Mariia Shalkova
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Antwerp (BE)
- Başkent University (TR)
- Universität Innsbruck (AT)
- Cornell University (US)
- McGill University Health Centre (CA)
- Meir Medical Center (IL)
- Samsung Medical Center (KR)
- Princess Margaret Cancer Centre (CA)
- Taipei Veterans General Hospital (TW)
- Fudan University Shanghai Cancer Center (CN)
- National Hospital Organization Kyushu Cancer Center (JP)
- Mount Vernon Cancer Centre (GB)
- Monash Health (AU)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- AZ Maria Middelares (BE)
- National University of La Rioja (AR)
- AGO Austria (AT)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Eisai (United Kingdom) (GB)
- Nord-Ostdeutsche Gesellschaft für Gynäkologische Onkologie (DE)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Eisai (United States) (US)
- Spanish Ovarian Cancer Research Group (ES)
- University of Rochester (US)
- Monash University (AU)
- Charité - Universitätsmedizin Berlin (DE)
- Sungkyunkwan University (KR)
- Saitama Medical University (JP)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1200/jco-24-01326
- Citations
- 46
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 26.81
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Genomic Health
- Regeneron Pharmaceuticals
- Fujirebio US
- Clovis Oncology
- BeiGene
- Seagen
- Eisai
- Novo Nordisk
- Astellas Pharma
- PharmaMar
- Ipsen
- LEO Pharma
- Genentech
- Defence and Security Accelerator
- Daiichi Sankyo Europe