MicroRNA-181a/b-1 enhances chondroprogenitor anabolism and downregulates aquaporin-9
Our findings demonstrate a pro-differentiation/anabolic function for miR-181a/b-1 during <i>in vitro</i> chondrogenesis that may be due, in part, to suppression of <i>AQP9</i>. Future studies are needed to elucidate the role of this membrane channel protein in regulating chondrocyte differentiation and homeostasis.
Authors
- Austin Bell‐Hensley (ORCID: https://orcid.org/0000-0003-1498-3012)
- Audrey McAlinden (ORCID: https://orcid.org/0000-0001-8433-4224)
- Victor Gustavo Balera Brito (ORCID: https://orcid.org/0000-0001-5508-3825)
- Kathryn Feeney
- Jin Liu (ORCID: https://orcid.org/0000-0002-1388-551X)
- Lei Cai (ORCID: https://orcid.org/0000-0002-8962-9723)
- Hongjun Zheng
Institutions
- Washington University in St. Louis (US)
- Shriners Hospitals for Children - St. Louis (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.ocarto.2024.100550
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- University of Washington
- National Institutes of Health
- Musculoskeletal Research Center, Washington University in St. Louis
- National Institute of Arthritis and Musculoskeletal and Skin Diseases