Expanded immune imprinting and neutralization spectrum by hybrid immunization following breakthrough infections with SARS-CoV-2 variants after three-dose vaccination
Overall, we demonstrated a persistent and expanded effect of immune imprinting from prior SARS-CoV-2 exposures. Thus, future vaccines should specifically address the latest variants, and booster shots should be given at a longer interval after the previous infection or vaccination.
Authors
- Nina Li
- Y Chen (ORCID: https://orcid.org/0009-0000-4787-0378)
- Chuming Luo
- Qiuyi Xu
- Fuxiang Wang (ORCID: https://orcid.org/0009-0000-0494-3717)
- Tingting Jia
- Yanqun Wang (ORCID: https://orcid.org/0000-0003-4676-2812)
- Jiani Wu (ORCID: https://orcid.org/0000-0001-7940-4179)
- Yuelong Shu (ORCID: https://orcid.org/0000-0001-6151-5540)
- Liangliang Wang (ORCID: https://orcid.org/0009-0006-2204-1892)
- Jiamin Chen (ORCID: https://orcid.org/0000-0003-0538-5520)
- Lifang Yuan (ORCID: https://orcid.org/0000-0002-6315-2824)
- Dongli Wang (ORCID: https://orcid.org/0000-0002-6704-1646)
- Qian Xie (ORCID: https://orcid.org/0000-0002-8290-2483)
- Huanle Luo (ORCID: https://orcid.org/0000-0002-7338-9972)
- Yongkun Chen (ORCID: https://orcid.org/0000-0001-7811-476X)
- Guancheng Liao
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Shenzhen University Health Science Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.jinf.2024.106362
- Citations
- 4
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.82