Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population
These findings support the validity of peripheral DNA methylation profiles for indirectly assessing hippocampal volume and development and underscore the importance of genotype and age considerations in research. Therefore, peripheral epigenetic profiles may be a promising avenue for investigating the impacts of early-life stress on brain structure and subsequent mental health outcomes.
Authors
- Daphne Koinis‐Mitchell (ORCID: https://orcid.org/0000-0002-5009-1647)
- Viren A. D’Sa (ORCID: https://orcid.org/0000-0002-3476-8419)
- Sophia Spencer
- B. Blair Braden (ORCID: https://orcid.org/0000-0001-6842-9784)
- Toni J. Hanson
- Jennifer Beauchemin
- Candace R. Lewis
- Phoebe Burton
- Fatoumata Barry
- Sarah E. Mennenga
- Sean Deoni (ORCID: https://orcid.org/0000-0002-0633-6328)
- Samantha A. Harker (ORCID: https://orcid.org/0009-0002-1271-3924)
Institutions
- Translational Genomics Research Institute (US)
- Gates Foundation (US)
- Brown University (US)
- Rhode Island Hospital (US)
- Arizona State University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.bpsgos.2024.100421
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Northwestern University
- Johns Hopkins University
- National Institutes of Health
- Johns Hopkins Bloomberg School of Public Health
- National Institute of Child Health and Human Development
- Office of Behavioral and Social Sciences Research
- Duke Clinical Research Institute
- Eunice Kennedy Shriver National Institute of Child Health and Human Development