High-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction
Imaging mass cytometry enables in-depth analyses of immune cell phenotypes in their local microenvironment. Using this approach, we identified major differences in cell populations in CLAD versus non-CLAD and in BOS versus RAS, with novel insights into the fibrotic progression of CLAD.
Authors
- Saskia Bos (ORCID: https://orcid.org/0000-0002-5336-5914)
- Julian Pulle
- Joaquim Majó Fernández (ORCID: https://orcid.org/0000-0001-6512-3253)
- David McDonald (ORCID: https://orcid.org/0000-0002-2410-9364)
- Andrew Filby (ORCID: https://orcid.org/0000-0001-9078-4360)
- Robin Vos (ORCID: https://orcid.org/0000-0002-3468-9251)
- George Merces (ORCID: https://orcid.org/0000-0001-7116-2451)
- Bart M. Vanaudenaerde (ORCID: https://orcid.org/0000-0001-6435-6901)
- Bethany Hunter (ORCID: https://orcid.org/0000-0002-9268-0511)
- Pauline Pradère (ORCID: https://orcid.org/0000-0003-4043-4666)
- Arno Vanstapel (ORCID: https://orcid.org/0000-0003-2412-8001)
- Andrew J. Fisher (ORCID: https://orcid.org/0000-0003-4822-7223)
- G. Sheldon
Institutions
- Université Paris-Saclay (FR)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Hôpital Marie Lannelongue (FR)
- Newcastle upon Tyne Hospital (GB)
- Newcastle University (GB)
- KU Leuven (BE)
Publication Details
- Journal
- The Journal of Heart and Lung Transplantation
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.healun.2024.11.021
- Citations
- 5
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- International Society for Heart and Lung Transplantation
- National Institute for Health and Care Research
- University of Cambridge
- Newcastle University
- KU Leuven