Phylogenetic and phylodynamic analysis of respiratory syncytial virus strains circulating in children less than five years of age in Karachi-Pakistan
Our results suggest that RSVA and RSVB strains in Pakistan exhibit distinct genotypic clusters and differ in their estimated tMRCA. Additionally, both genotypes showed glycosylation and selection pressure at specific sites, with RSVB exhibiting higher nucleotide divergence per site (π), indicating its potential to undergo further evolutionary changes and adaptation. Overall, this study provides unique insights into RSV molecular epidemiology. The study may also help improve our understanding of RSV evolutionary changes and the emergence of new genotypes in different regions worldwide and within Pakistan.
Authors
- Fátima Aziz (ORCID: https://orcid.org/0000-0002-9836-9142)
- Wardah Rafaqat (ORCID: https://orcid.org/0000-0002-7224-486X)
- Mahnoor Javaid (ORCID: https://orcid.org/0000-0002-1501-1031)
- Asad Ali (ORCID: https://orcid.org/0000-0001-5274-7665)
- Tanveer Abbas (ORCID: https://orcid.org/0000-0002-1784-3077)
- Nida Farooqui (ORCID: https://orcid.org/0000-0003-1515-9690)
- Syed H. Abid
- Alnara Zhamalbekova
Institutions
- Aga Khan University (PK)
- University of Karachi (PK)
- Nazarbayev University (KZ)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.meegid.2024.105694
- Citations
- 3
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Nazarbayev University
- National Institutes of Health
- Fogarty International Center