Application of TCM network pharmacology and experimental verification to explore the mechanism of kaempferol against epilepsy
These results indicate that KF's anticonvulsant properties may arise from its neuroprotection against cell injury, edema, and necrosis, its reduction of neuronal hyperexcitability, and its prevention of calcium-induced cytotoxicity, potentially involving AMPAR modulation. This study positions KF as a promising candidate for epilepsy therapy, offering a scientific foundation for its clinical investigation.
Authors
- Zhanfeng Jia
- Jiaojiao Zhao
- Qing‐Hui Guo (ORCID: https://orcid.org/0000-0002-9946-0810)
- Siruan Chen (ORCID: https://orcid.org/0009-0001-7449-4432)
- Dezhi Kong
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-3967-6548)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-9825-0371)
- Xia Qin (ORCID: https://orcid.org/0000-0003-0412-0352)
- Han Guo (ORCID: https://orcid.org/0009-0009-7544-6561)
- Lei Yang (ORCID: https://orcid.org/0000-0002-9153-2664)
- Wenya Zhao
- Kaiyue Tian
- Zuxiao Yang
Institutions
- Hebei Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111150
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.27