FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results
These results suggest that the UHDR irradiations can improve the safety and effectiveness of heavy ion therapy, and provide a crucial benchmark for current mechanistic FLASH models. However, additional experiments are needed to validate these findings across other animal and tumor models.
Authors
- Stefan Janssen (ORCID: https://orcid.org/0000-0003-2697-6362)
- Denise Eckert (ORCID: https://orcid.org/0000-0002-7304-8799)
- Anna Rehm (ORCID: https://orcid.org/0009-0000-5063-486X)
- Felix Horst (ORCID: https://orcid.org/0000-0003-0707-0856)
- Julius Oppermann
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Claudia Fournier (ORCID: https://orcid.org/0000-0002-1007-9934)
- Daria Boscolo (ORCID: https://orcid.org/0000-0001-5709-4472)
- Christoph Schuy (ORCID: https://orcid.org/0000-0001-8407-9358)
- Olga Sokol (ORCID: https://orcid.org/0000-0003-3664-7538)
- Walter Tinganelli (ORCID: https://orcid.org/0000-0003-0844-7272)
- Uli Weber (ORCID: https://orcid.org/0000-0002-8147-0084)
- Ralf Moeller (ORCID: https://orcid.org/0000-0002-2371-0676)
- Sylvie Lerchl
- Palma Simoniello (ORCID: https://orcid.org/0000-0003-2888-2642)
- Denise Engel
- Rossana Romano
- Alexander Helm
- Anggraeini Puspitasari-Kokko
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Parthenope University of Naples (IT)
- Justus-Liebig-Universität Gießen (DE)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.ijrobp.2024.11.089
- Citations
- 15
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 6.28