Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α
Taken together, our study provides evidence that LPXN plays a critical role in modulating hepatic gluconeogenesis, thereby reinforcing the fact that targeting LPXN may be a potential approach for the treatment of diabetes and metabolic disorders.
Authors
- Xiaoyin Ding (ORCID: https://orcid.org/0009-0005-5491-2966)
- Yongde Peng (ORCID: https://orcid.org/0000-0001-9388-4922)
- Ruizhe Shen (ORCID: https://orcid.org/0000-0001-5201-3856)
- Caizhi Liu
- Xiaofang Tang (ORCID: https://orcid.org/0009-0002-2972-8778)
- Fang Liu (ORCID: https://orcid.org/0000-0002-8325-1213)
- Yufan Wang (ORCID: https://orcid.org/0000-0001-9614-3986)
- Lijun Zhu (ORCID: https://orcid.org/0000-0002-7854-0424)
- Zhijian Zhang
- Xiaomin Luo (ORCID: https://orcid.org/0000-0003-0426-3417)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Tongren Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1016/j.molmet.2024.102075
- Citations
- 1
- Primary Topic
- Microbial Metabolites in Food Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- East China Normal University
- Changjiang River Scientific Research Institute
- NIH Clinical Center