Regression to the mean for physical function and quality of life in clinical trials for symptomatic knee osteoarthritis
RTM in trials for knee OA is likely to explain improvement in physical function and QOL, not only in knee pain. RTM often misleads investigators to overinterpret effectiveness as RTM neither represents improvement from the intervention nor placebo effect from the intervention and its context.
Authors
- Aleksandra Turkiewicz (ORCID: https://orcid.org/0000-0003-1460-2275)
- Martin Englund (ORCID: https://orcid.org/0000-0003-3320-2437)
Institutions
- Lund University (SE)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1016/j.joca.2024.11.006
- Citations
- 8
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Pfizer
- GlaxoSmithKline
- National Institutes of Health