GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
Through highly sensitive and selective technologies we show Gfral expression is overwhelmingly restricted to the brainstem and expect that GDF15 and GFRAL-based therapies in development for cancer cachexia will specifically target AP/NTS cells.
Authors
- Fernando Alvarez (ORCID: https://orcid.org/0000-0002-3864-5790)
- Paul V. Sabatini (ORCID: https://orcid.org/0000-0001-6613-566X)
- Nadejda Bozadjieva-Kramer (ORCID: https://orcid.org/0000-0001-9796-2916)
- Ciriaco A. Piccirillo (ORCID: https://orcid.org/0000-0002-7703-6779)
- Randy J. Seeley (ORCID: https://orcid.org/0000-0002-3721-5625)
- Cecilia Hes (ORCID: https://orcid.org/0000-0002-4828-3260)
- Pierce Katz
- Alexandre Bay
- T. Paul
- Luting Gui
Institutions
- University of Michigan (US)
- McGill University Health Centre (CA)
- VA Ann Arbor Healthcare System (US)
- McGill University (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.molmet.2024.102070
- Citations
- 13
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.11
Funders
- U.S. Department of Veterans Affairs
- Amgen
- Eli Lilly and Company
- McGill University
- McGill University Health Centre
- Novo Nordisk
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada