Synthesis of 1,3,4-Oxadiazoles from 1,2-Diacylhydrazines Using SO2F2 as a Simple and Practical Cyclization Reagent
Abstract The synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines has been achieved using SO₂F₂ as a straightforward and effective reagent for dehydrative cyclisation, both in the absence of metal catalysts and under milder conditions. The reaction exhibited good functional group tolerance and yielded high levels of product.
Authors
- Zhengzheng Lou (ORCID: https://orcid.org/0000-0002-6902-5260)
- Chengrong Ding (ORCID: https://orcid.org/0000-0001-6000-3965)
- Han Jin (ORCID: https://orcid.org/0000-0001-7427-4600)
- Jiefu Chen (ORCID: https://orcid.org/0000-0001-9940-7043)
- Guofu Zhang (ORCID: https://orcid.org/0000-0002-6715-5520)
Institutions
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Synlett
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1055/a-2489-7481
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00