Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model
This study successfully established a reliable mouse model for PS, highlighting the significant roles of mechanical tension and chronic inflammation in PS formation. We identified Sele as a key therapeutic target and developed Sele-targeted siRNA LNPs, which demonstrated potential as a preventive strategy for PS. These findings provide valuable insights into PS pathogenesis and open new avenues for developing effective treatments for pathological scars.
Authors
- Yan Wo
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-7905-7269)
- Jing Meng (ORCID: https://orcid.org/0000-0003-0320-6859)
- Xiaojin Wu (ORCID: https://orcid.org/0000-0002-9213-3884)
- Luyu Li
- Ying Shang (ORCID: https://orcid.org/0000-0001-7810-2494)
- Xue Wang (ORCID: https://orcid.org/0009-0006-7955-4410)
- Yong Wang (ORCID: https://orcid.org/0009-0005-0832-4426)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12951-024-03003-4
- Citations
- 7
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Natural Science Foundation of Shanghai
- China Postdoctoral Science Foundation
- Shanghai Jiao Tong University