METTL2B m3C RNA transferase: oncogenic role in ovarian cancer progression via regulation of the mTOR/AKT pathway and its link to the tumor immune microenvironment
Our research confirmed the upregulation of METTL2B in OC, suggesting its oncogenic function. However, METTL2B expression was negatively correlated with the infiltration scores of multiple immune cells, including cytotoxic cells and T cells, indicating its complex role in the tumor immune microenvironment. These findings highlight the significant clinical value of METTL2B in the diagnosis and prognosis of OC.
Authors
- Yimei Meng (ORCID: https://orcid.org/0000-0001-7489-5634)
- Hui Zheng (ORCID: https://orcid.org/0000-0003-2930-4641)
- Peiling Li (ORCID: https://orcid.org/0000-0002-1894-235X)
- Yanhong Shan (ORCID: https://orcid.org/0000-0002-7279-3527)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Junhaohui Huo (ORCID: https://orcid.org/0009-0006-6848-3987)
- Yizi Meng
Institutions
- Harbin Medical University (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s12885-024-13225-2
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Jilin University
- First Hospital of Jilin University