Visium spatial transcriptomics and proteomics identifies novel hepatic cell populations and transcriptomic signatures of alcohol‐associated hepatitis
This study identified global cell type alterations in AH and distinct transcriptomic changes between AH and non-ALD controls. These findings characterize cellular plasticity and profuse transcriptomic and proteomic changes that are apparent in AH and contribute to the identification of novel therapeutics.
Authors
- Elizabeth Hudson (ORCID: https://orcid.org/0000-0001-7349-1080)
- Craig J. McClain (ORCID: https://orcid.org/0000-0002-7219-8939)
- Tyler C. Gripshover (ORCID: https://orcid.org/0000-0003-2191-9107)
- Julia H. Chariker (ORCID: https://orcid.org/0000-0001-6805-7220)
- R Trèves
- Eric C. Rouchka (ORCID: https://orcid.org/0000-0003-3487-6572)
- Melissa Laird Smith (ORCID: https://orcid.org/0000-0001-7151-3207)
- Josiah Hardesty (ORCID: https://orcid.org/0000-0003-1955-3046)
- Shirong Zheng
- Ashwani Kumar Singal (ORCID: https://orcid.org/0000-0003-1207-3998)
Institutions
- University of Louisville (US)
- Louisville VA Medical Center (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1111/acer.15494
- Citations
- 5
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of General Medical Sciences