Facile Ru-catalysed synthesis of quinazolin-4(3<i>H</i>)-ones by tandem cyclization of 2-nitrobenzonitrile and alcohol derivatives under air
We have developed an efficient approach for the first Ru-catalysed synthesis of 2-arylquinazolin-4(3<i>H</i>)-ones from 2-nitrobenzonitriles and alcohols. This method features a broad substrate scope, high yields, and functional group tolerance and does not require any oxidant or reductant, allowing for simple, practical and sustainable synthesis.
Authors
- Phan Thiện Vy
- Nguyễn Trọng Tuân (ORCID: https://orcid.org/0000-0002-5626-5660)
- Tuan Thanh Dang (ORCID: https://orcid.org/0000-0003-1014-318X)
- Hien Nguyen (ORCID: https://orcid.org/0000-0002-4132-9684)
- Ban Van Phuc (ORCID: https://orcid.org/0000-0003-4861-8371)
- Ngọc Tuấn Nguyễn (ORCID: https://orcid.org/0000-0002-1865-6628)
- Quốc Anh Ngô (ORCID: https://orcid.org/0000-0002-3550-9689)
- Phuong Anh Dao
- Dat T. Nguyen (ORCID: https://orcid.org/0009-0007-0723-3615)
- Tran Quang Hung (ORCID: https://orcid.org/0000-0001-9867-9207)
Institutions
- Hanoi National University of Education (VN)
- Vietnam National University, Hanoi (VN)
- VNU University of Science (VN)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1039/d4ob01786b
- Citations
- 4
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.00