Phosphonamidates of Camphorsultam: Versatile Building Blocks for the Synthesis of <i>P</i>‐Chiral Phosphorous(V) Compounds

Abstract Camphorsultam was utilized for the optical resolution of P ‐chiral phosphorous compounds. After chromatographic separation of diastereomeric R P ‐ and S P ‐phosphonamidate intermediates, subsequent substitution reactions with phenol derivatives yielded P ‐chiral phosphonic acid aryl esters with excellent enantioselectivities. In these processes, chiral sulfonamide of camphorsultam demonstrated superior abilities as an optical‐resolving agent and a good leaving group. This method was applied to the synthesis of P ‐chiral phosphinic esters, phosphonamidates, and thiophosphonate diesters.