Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis
This is the first mechanistic mathematical model of ET-1 kinetics that describes receptor-mediated clearance, and the consequence of ET<sub>B</sub> blockade on ET-1 concentrations. It provides a useful tool that can coupled with experimental studies to quantitively understand and investigate this complex and dynamic system.
Authors
- K. Melissa Hallow (ORCID: https://orcid.org/0000-0002-8156-2245)
- Peter J. Greasley (ORCID: https://orcid.org/0000-0002-2529-4477)
- Hiddo J.L. Heerspink (ORCID: https://orcid.org/0000-0002-3126-3730)
- Hongtao Yu (ORCID: https://orcid.org/0000-0003-2278-4478)
Institutions
- University of Georgia (US)
- University of Groningen (NL)
- The George Institute for Global Health (AU)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (United States) (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3389/fphar.2024.1332388
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- AstraZeneca