SYNTHESIS, ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF PLATINUM (II) AND PALLADIUM (II) COMPLEXES

The aim of the work is the synthesis of mono- and binuclear complexes of platinum (II) and palladium (II) containing terminal and bridging atoms of chlorine and sulfur as ligands and the study of their biological activity in relation to test cultures of Bacillus subtilis B4647, Aspergillus brasiliensis (niger) F679, Pseudomonas aeruginosa B8243, Escherichia coli. The composition and structure of the synthesized platinum (II) and palladium (II) complexes were established by methods of elemental analysis, X-ray photoelectron spectroscopy (XPS), IR spectroscopy, and X-ray diffraction (XRD) technique, which correspond to our results on the X-ray structural analysis of these complexes. Antimicrobial and antifungicidal properties were assessed by the ability of the synthesized complexes to suppress the vital activity of bacteria and fungi using the agar diffusion method and the in vitro dilution method. The results obtained showed high activity of the binuclear complex of palladium (II) (μ-S)[Pd2(SCH2CH2NH+ 3)2Cl4] and platinum (II) (μ-Cl)[Pt2(SCH2CH2NH2)2Cl2]∙3H2O of non-electrolyte type. Binuclear complexes of palladium and platinum, in contrast to mononuclear trans-[Pd(SCH2CH2NH2)2] and cis-[Pt(SCH2CH2NH2)2], exhibit higher antibacterial activity. The effectiveness of the antibacterial action of the non-electrolyte palladium complex against the bacteria Bacillus subtilis, Escherichia coli and fungi Aspergillus niger was more pronounced. The results of our study showed that by changing the structure of the complex, the composition and charge of the inner sphere, the number of coordination centers, the nature and dentacy of the ligands, it is possible to achieve a higher toxic effect of the complexes (μ-S [Pd2(SCH2CH2NH+ 3)2Cl4], μ-Cl [Pt2(SCH2CH2NH2)2Cl2]∙3H2O) in relation to bacteria and fungi.