Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa
This study underscores the significant relationship observed prior to therapy initiation between the number of defective proviruses, viral transcription/production and their association with immune response indicators such as CD4 count, CXCL10, and TNF-α. Furthermore, the observation of a less pronounced decrease of the defective proviral DNA highlights the importance of addressing both intact and defective proviruses in therapeutic strategies to enhance clinical outcomes for people with HIV-1. Together, these findings suggest a significant role of the defective proviruses in HIV-related disease progression.
Authors
- Chijioke N. Umunnakwe (ORCID: https://orcid.org/0000-0001-5879-8658)
- Monique Nijhuis (ORCID: https://orcid.org/0000-0001-6610-8282)
- Ninée V. E. J. Buchholtz (ORCID: https://orcid.org/0000-0002-4545-7536)
- Irma Maurer (ORCID: https://orcid.org/0000-0003-2864-2139)
- Marieke M. Nühn (ORCID: https://orcid.org/0000-0002-4360-0431)
- Lucas E. Hermans (ORCID: https://orcid.org/0000-0002-8741-5852)
- Annemarie M. J. Wensing (ORCID: https://orcid.org/0000-0003-3790-8891)
- Neeltje A. Kootstra (ORCID: https://orcid.org/0000-0001-9429-7754)
- Dorien C. M. de Jong
- Hugo Tempelman
- Jori Symons (ORCID: https://orcid.org/0000-0001-6560-1577)
- Rose M. Voss
- Emma Need
Institutions
- University of the Witwatersrand (ZA)
- University Medical Center Utrecht (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3389/fimmu.2024.1484358
- Citations
- 7
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.06