FGTI-2734 Inhibits ERK Reactivation to Overcome Sotorasib Resistance in KRAS G12C Lung Cancer
Our findings provide a foundation for overcoming sotorasib resistance and potentially improving the treatment outcomes of KRAS G12C lung cancer.
Authors
- Hitesh Vasiyani (ORCID: https://orcid.org/0009-0005-3767-6893)
- Dipankar Bandyopadhyay (ORCID: https://orcid.org/0000-0002-9703-5300)
- Vignesh Vudatha (ORCID: https://orcid.org/0000-0002-3624-3771)
- Aslamuzzaman Kazi (ORCID: https://orcid.org/0009-0005-7403-7468)
- Rachit D. Shah (ORCID: https://orcid.org/0000-0002-3632-3034)
- Deblina Ghosh
- Jose Trevino (ORCID: https://orcid.org/0000-0003-3149-7761)
- Saı̈d M. Sebti (ORCID: https://orcid.org/0000-0001-5163-1038)
Institutions
- Virginia Commonwealth University (US)
- Comprehensive Cancer Center Vienna (AT)
Publication Details
- Journal
- Journal of Thoracic Oncology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.jtho.2024.11.022
- Citations
- 5
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health
- National Cancer Institute