Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates
This study finds an increase in exacerbation rate among patients with T2 high inflammation with asthma and shows a dose-dependent response to AEC. To our knowledge, this is the first study to find effect modification by sex and T2 status, identifying a group of patients who could potentially benefit from T2-targeted biologic therapy to decrease their exacerbation rate.
Authors
- Sunita Sharma (ORCID: https://orcid.org/0000-0001-7179-6059)
- Zachary J. Taich (ORCID: https://orcid.org/0000-0002-2533-0888)
- Guillermo Jimenez
- Trisha Agarwal
- Fernando Holguín (ORCID: https://orcid.org/0000-0003-0979-8234)
- Meghan D. Althoff (ORCID: https://orcid.org/0000-0002-3638-7011)
- Ryan Peterson (ORCID: https://orcid.org/0000-0002-4650-5798)
Institutions
- Colorado School of Public Health (US)
- West Coast University (US)
- University of California System (US)
- University of California San Diego (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- CHEST Pulmonary
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.chpulm.2024.100123
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Francis Family Foundation
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences