SYNTHESIS OF UREAS COMBINING ADAMANTANE AND MONOTERPENOID FRAGMENTS AND STUDY OF THEIR ACTIVITY AGAINST THE SARS-COV-2 VIRUSES
A series of ureas containing adamantane and monoterpenoid residues has been synthesised. All compounds were tested in vitro using a pseudoviral system containing the S glycoprotein of the SARS-CoV-2 virus and infectious SARS-CoV-2 viruses of various strains on its surface. Compound 4a demonstrated high activity against four strains of SARS-CoV-2.
Authors
- Peiwen Yu (ORCID: https://orcid.org/0000-0003-4975-6151)
- 영미 이
- Susan Silvia. N. (ORCID: https://orcid.org/0009-0007-6699-449X)
- SUSLOV E.V.
- P. V.
- Mrs. Bijilin Reeni. D
- MOZHAITSEV E.S.
- SALAKHUTDINOV N.F.
- ZAYKOVSKAYA A.V.
Institutions
- State Research Center of Virology and Biotechnology VECTOR (RU)
- Novosibirsk Institute of Organic Chemistry (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- Химия в интересах устойчивого развития
- Published
- 2024-08-31
- DOI
- https://doi.org/10.15372/csd2024584
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00