Associations of Mild Behavioral Impairment Domains with Brain Volumes: Cross-sectional Analysis of Atherosclerosis Risk in Community (ARIC) Study
In this community-dwelling population of older adults without dementia, MBI symptoms were associated with lower GM volumes in regions commonly implicated in early Alzheimer's disease pathology. These findings lend support to the notion that MBI symptoms may be useful in identifying individuals at risk for future dementia.
Authors
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Zahinoor Ismail (ORCID: https://orcid.org/0000-0002-5529-3731)
- Lisa Young (ORCID: https://orcid.org/0000-0002-7184-6009)
- Lisa N. Richey (ORCID: https://orcid.org/0000-0001-8050-1240)
- Andrea L.C. Schneider (ORCID: https://orcid.org/0000-0003-0026-5052)
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- Aaron I. Esagoff (ORCID: https://orcid.org/0000-0001-8433-5091)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Khaled Moussawi (ORCID: https://orcid.org/0000-0001-6378-0428)
- Connor A. Law (ORCID: https://orcid.org/0009-0008-5084-7089)
- Matthew E. Peters (ORCID: https://orcid.org/0000-0002-5668-4566)
- Srishti Shrestha
Institutions
- Mayo Clinic (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University of Exeter (GB)
- Johns Hopkins Medicine (US)
- University of Mississippi Medical Center (US)
- University of Mississippi (US)
- Behavioral Pharma (United States) (US)
- National Institute of Neurological Disorders and Stroke (US)
- Mayo Clinic in Arizona (US)
- NIHR Exeter Clinical Research Facility (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of the Academy of Consultation-Liaison Psychiatry
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.jaclp.2024.11.003
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- U.S. Department of Defense
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke