Total syntheses of Kavaratamide A and 5- <i>epi</i> -Kavaratamide A

The total synthesis of Kavaratamide A, a new Linear Lipodepsipeptide from the Marine Cyanobacterium <i>Moorena bouillonii</i> was achieved by assembling the side chain in stage through condensation coupling, carbon-chain extension, Steglich esterification and Evans aldol reaction. In addition, total synthesis of Kavaratamide A's isomer, 5-<i>epi</i>-kavaratamide A, is also successfully achieved. Cytotoxicity test suggested that Kavaratamide A and 5-<i>epi</i>-Kavaratamide A have a moderate bioactivity against cancer cells.