TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis
TGR5 in SF1 neurons favours satiety by differently modifying the meal pattern in response to specific metabolic cues. These studies also reveal a novel key function for TGR5 in SF1 neurons in the regulation of whole-body insulin sensitivity, providing new insight into the role played by neuronal TGR5 in the regulation of metabolism.
Authors
- Selma Yagoub
- Ashley Castellanos-Jankiewicz (ORCID: https://orcid.org/0000-0001-9080-7593)
- Kristina Schoonjans (ORCID: https://orcid.org/0000-0003-1247-4265)
- Delphine Gonzales (ORCID: https://orcid.org/0000-0002-6307-4280)
- Philippe Zizzari (ORCID: https://orcid.org/0000-0001-8838-0762)
- Marlène Maître
- Daniela Cota (ORCID: https://orcid.org/0000-0002-6909-2156)
- Thierry Lesté-Lasserre (ORCID: https://orcid.org/0000-0001-8328-3816)
- Vincent Simon (ORCID: https://orcid.org/0000-0002-1751-218X)
- Valérie S. Fénelon (ORCID: https://orcid.org/0000-0001-8023-0049)
- Nathalie Dupuy (ORCID: https://orcid.org/0000-0002-8739-2689)
- Samantha Clark
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- Neurocentre Magendie (FR)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1016/j.molmet.2024.102071
- Citations
- 3
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.82
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Labex
- Université de Bordeaux
- LabEx BRAIN