Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target
In conclusion, our findings not only provide comprehensive and integrated perspectives of molecular underpinnings of LC-BrMs but also contribute to the development of a potential, rationale-based combinatorial therapeutic strategy with the goal of translating it into clinical trials for patients with LC-BrMs.
Authors
- Zhi Wei (ORCID: https://orcid.org/0000-0001-6059-4267)
- Suwen Wu
- Shiyou Wei (ORCID: https://orcid.org/0000-0002-1783-0372)
- Maojin Yao (ORCID: https://orcid.org/0000-0002-7805-8304)
- Lun Liang (ORCID: https://orcid.org/0000-0002-0666-9894)
- Xiangheng Zhang
- Eric Sugarman (ORCID: https://orcid.org/0000-0003-3654-0773)
- Hao Duan (ORCID: https://orcid.org/0000-0002-7078-8900)
- Zhenning Wang (ORCID: https://orcid.org/0000-0003-0557-3097)
- Jianlan Ren (ORCID: https://orcid.org/0009-0000-1875-3244)
- Likun Chen (ORCID: https://orcid.org/0000-0002-7158-3878)
- Zhen Zeng (ORCID: https://orcid.org/0000-0002-9055-217X)
- Yu Jiang (ORCID: https://orcid.org/0000-0003-0716-4334)
- Yonggao Mou (ORCID: https://orcid.org/0000-0001-6045-503X)
- Xiuqi Wang (ORCID: https://orcid.org/0000-0003-2033-9485)
- Chengwei Yu (ORCID: https://orcid.org/0000-0001-9915-5739)
- Houde Li
- Rebecca A. Deek (ORCID: https://orcid.org/0000-0002-8783-4694)
- Gao Zhang (ORCID: https://orcid.org/0000-0001-8617-8886)
- Lunxu Liu (ORCID: https://orcid.org/0000-0003-3964-5378)
- Wanming Hu (ORCID: https://orcid.org/0000-0002-3632-1258)
- Chengcheng Guo (ORCID: https://orcid.org/0000-0003-0857-0350)
- Yaohui Chen (ORCID: https://orcid.org/0000-0002-6996-9819)
- Yu Liu (ORCID: https://orcid.org/0009-0005-5475-2632)
- Chuan Li (ORCID: https://orcid.org/0000-0002-4381-3891)
- Yuan Xie (ORCID: https://orcid.org/0000-0002-4901-146X)
- Zhenyu Yang (ORCID: https://orcid.org/0000-0002-4050-0320)
- Zexin Chen (ORCID: https://orcid.org/0000-0002-2685-4501)
- Meichen Li (ORCID: https://orcid.org/0000-0003-3201-045X)
- Tao Li (ORCID: https://orcid.org/0000-0001-6092-8482)
- Hongbin Lan
- Maodi Xie
- Yanhao Mou
Institutions
- Philadelphia College of Osteopathic Medicine (US)
- New Jersey Institute of Technology (US)
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Sichuan University (CN)
- Prince Philip Dental Hospital (CN)
- West China Hospital of Sichuan University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Dongguan People’s Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Southern Medical University (CN)
- University of Pennsylvania (US)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s13073-024-01410-8
- Citations
- 26
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 10.89
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province
- Sichuan Province Science and Technology Support Program
- West China Hospital, Sichuan University
- Basic and Applied Basic Research Foundation of Guangdong Province