USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis
This study reveals a novel mechanism of USP33 in promoting laminin-dependent ESCC cell migration and metastasis through integrin α6, suggesting that USP33 may be a promising target for treating ESCC.
Authors
- Sicong Hou (ORCID: https://orcid.org/0000-0001-8641-3743)
- Haifeng Huang (ORCID: https://orcid.org/0009-0009-4189-4657)
- Shi Zuo (ORCID: https://orcid.org/0000-0002-8595-5062)
- Ya‐Wen Yang (ORCID: https://orcid.org/0000-0003-0412-584X)
- Jingya Guo (ORCID: https://orcid.org/0000-0002-5576-5268)
- Qinglei Hang (ORCID: https://orcid.org/0000-0003-0419-6621)
- Caimin Li
- Wenqian Li (ORCID: https://orcid.org/0000-0001-6663-9809)
- Yuanzhi Wang (ORCID: https://orcid.org/0000-0002-7500-022X)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1007/s00432-024-06041-5
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province