Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in ApcMin/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis

We identified the ERα-ERRα-SPP1 signaling axis as a potential key mediator in GCR-induced breast cancer with conserved activation in human breast cancer. These findings suggest that targeting this pathway could serve as a potential target for therapeutic intervention to safeguard female astronauts during and after a prolonged outer space mission.

Authors

Shubhankar Suman (ORCID: https://orcid.org/0000-0002-9197-0461)
Albert J. Fornace (ORCID: https://orcid.org/0000-0001-9695-085X)
Jerry Angdisen
Kamendra Kumar (ORCID: https://orcid.org/0000-0002-3091-8520)
Kamal Datta
Jiaojiao Ma (ORCID: https://orcid.org/0000-0001-9731-3529)

Institutions

Georgetown University (US)
Georgetown University Medical Center (US)

Publication Details

Journal: Cancers
Published: 2024-11-26
DOI: https://doi.org/10.3390/cancers16233954
Citations: 7
Primary Topic: Estrogen and related hormone effects
Type: article
Field-Weighted Citation Impact: 3.85

Funders

National Aeronautics and Space Administration
National Synchrotron Radiation Laboratory

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article

Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in ApcMin/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis

Shubhankar Suman, Albert J. Fornace, Jerry Angdisen, Kamendra Kumar et al.

Nov 26, 2024

7 citations

Cancers

Estrogen and related hormone effects

3.85

article

Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in ApcMin/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis

Shubhankar Suman, Albert J. Fornace, Jerry Angdisen, Kamendra Kumar, Kamal Datta, Jiaojiao Ma

November 26, 2024article en

7 citations

Abstract

We identified the ERα-ERRα-SPP1 signaling axis as a potential key mediator in GCR-induced breast cancer with conserved activation in human breast cancer. These findings suggest that targeting this pathway could serve as a potential target for therapeutic intervention to safeguard female astronauts during and after a prolonged outer space mission.

CancersVol. 16(23)

Georgetown University (US), Georgetown University Medical Center (US)

National Aeronautics and Space Administration, National Synchrotron Radiation Laboratory

Good health and well-being

Openalex Percentile: Top 6%

Estrogen and related hormone effects

3.85

DOI Open Access PDF OpenAlex

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Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in ApcMin/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis — Shubhankar Suman, Albert J. Fornace, et al. · Cancers (2024) | TGRS Research Map | TGRS