Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction
A series of 1,5-disubstituted tetrazole-indole hybrids were synthesized via a high-order multicomponent reaction consisting of an Ugi-azide/Pd/Cu-catalyzed hetero-annulation cascade sequence. This operationally simple one-pot protocol allowed high bond-forming efficiency and creating six new bonds (two C-C, three C-N, and one N-N). Additionally, the products were evaluated against breast cancer MCF-7 cells, finding moderate activity in the compounds substituted with fluorine and chlorine.
Authors
- Jorge Gustavo Araujo-Huitrado
- Yamilé López‐Hernández (ORCID: https://orcid.org/0000-0002-1068-603X)
- Jesús Adrián López (ORCID: https://orcid.org/0000-0001-8012-7041)
- Luis Chacón-Garcı́a (ORCID: https://orcid.org/0000-0001-8877-4817)
- Alejandro Islas‐Jácome (ORCID: https://orcid.org/0000-0003-0975-5904)
- Carlos Jesus Cortés-Garcia (ORCID: https://orcid.org/0000-0003-4632-6316)
- Angélica Judith Granados‐López (ORCID: https://orcid.org/0000-0002-7894-0735)
- Cesia M. Aguilar-Morales
- Hiram Hernández‐López (ORCID: https://orcid.org/0000-0002-4286-163X)
- América A. Frías-López
- Nadia V Emilio-Velázquez
Institutions
- Universidad Michoacana de San Nicolás de Hidalgo (MX)
- Universidad Autónoma Metropolitana (MX)
- Secretaría de Ciencia, Humanidades, Tecnología e Innovación (MX)
- Universidad Autónoma de Zacatecas "Francisco García Salinas" (MX)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3762/bjoc.20.256
- Citations
- 1
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Universidad Michoacana de San Nicolás de Hidalgo