Modulatory Effects of Photobiomodulation on Oxidative and Inflammatory Responses in a Murine Model of Periodontitis
Periodontitis, an oral disease initiated by a dysbiotic dental biofilm, has an unclear response to photobiomodulation (PBM) as an adjunctive treatment. This study investigates the effects of PBM on reactive oxygen species (ROS), apoptosis, oxidative stress, and inflammatory markers in a periodontitis model using C57BL/6 mice, divided into four groups: control (C), control + PBM (C + PBM), periodontitis (P), and periodontitis + PBM (P + PBM). An infrared diode laser (808 nm, 133.3 J/cm<sup>2</sup>, 4 J/session) was applied for three days. PBM reduced superoxide anions, hydrogen peroxide, and apoptosis in gingival cells, while decreasing systemic inflammation and protein oxidation. In the P + PBM group, pro-inflammatory cytokines IL-6 and IL-12p70 decreased, whereas IL-10 increased, suggesting improvements in oxidative stress and inflammation profiles.
Authors
- Isadora Martins Ribeiro
- Silvana S. Meyrelles (ORCID: https://orcid.org/0000-0003-0167-4093)
- Edgar Hell Kampke (ORCID: https://orcid.org/0000-0003-4524-4896)
- Maria Eduarda de Souza Barroso (ORCID: https://orcid.org/0000-0002-7696-0919)
- Sara Andrade (ORCID: https://orcid.org/0000-0001-9825-2772)
- Marcella L. Porto
- Larissa Braga (ORCID: https://orcid.org/0009-0002-1290-6881)
- Giovanna Lopes de Sousa Barbosa
- Lorena Nascimento Santos Neves (ORCID: https://orcid.org/0009-0003-7182-6635)
Institutions
- Universidade Federal do Espírito Santo (BR)
Publication Details
- Journal
- Antioxidants
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3390/antiox13121450
- Citations
- 3
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Espírito Santo
- Universidade Federal do Espírito Santo