Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes
We have performed the first high-throughput urinary metabolomics analysis on CAD in individuals with type 1 diabetes and found xanthosine, 3-hydroxyisobutyrate, trans-aconitate, and 4-deoxythreonate to be associated with incident CAD. In addition, metabolomic state profiling improved prediction of incident CAD.
Authors
- Per‐Henrik Groop (ORCID: https://orcid.org/0000-0003-4055-6954)
- Anni A. Antikainen (ORCID: https://orcid.org/0000-0003-2488-6830)
- Niina Sandholm (ORCID: https://orcid.org/0000-0003-4322-6942)
- Valma Harjutsalo (ORCID: https://orcid.org/0000-0003-3568-9779)
- Lena M. Thorn (ORCID: https://orcid.org/0000-0003-3999-0390)
- Stefan Mutter (ORCID: https://orcid.org/0000-0002-8293-6982)
Institutions
- University of Helsinki (FI)
- Baker Heart and Diabetes Institute (AU)
- Helsinki University Hospital (FI)
- Institute for Molecular Medicine Finland (FI)
- Folkhälsans Forskningscentrum (FI)
- Monash University (AU)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s12933-024-02512-8
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Foundation for Cardiovascular Research
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Wilhelm och Else Stockmanns Stiftelse
- Aarne Koskelon Säätiö
- Folkhälsanin Tutkimussäätiö
- Novo Nordisk
- Samfundet Folkhälsan
- Sydäntutkimussäätiö
- Sigrid Juséliuksen Säätiö
- Novo Nordisk Fonden