Disruption of PCSK9 Suppresses Inflammation and Attenuates Abdominal Aortic Aneurysm Formation
PCSK9 critically mediates macrophage inflammation and elastin degradation, promoting AAA formation. PCSK9 inhibitors bear a promise to curtail AAA, beyond being used as cholesterol-lowering drugs.
Authors
- Shuangjie Lv
- Zekun Peng
- Hou‐Zao Chen (ORCID: https://orcid.org/0000-0001-6805-3182)
- Yuze Zhang (ORCID: https://orcid.org/0000-0002-5869-2033)
- De‐Pei Liu (ORCID: https://orcid.org/0000-0002-2636-4297)
- Haojie Rao (ORCID: https://orcid.org/0009-0006-9156-2480)
- Miao Wang (ORCID: https://orcid.org/0000-0002-0532-6312)
- Qing Wan (ORCID: https://orcid.org/0009-0006-6348-7006)
- Ziwei Guo
- Jianfeng Yang
- Hong Chen (ORCID: https://orcid.org/0000-0001-5379-6725)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1161/atvbaha.123.320391
- Citations
- 14
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.87