Target-controlled dialysis for antibiotics (TCD-ABx)
We outlined the mechanistic plausibility and provided experimental evidence of the feasibility of the target-controlled dialysis concept, which could help to maintain therapeutic concentrations of many time-dependent antibiotics in critically ill patients under renal replacement therapy. The required stability in dialysis solutions was shown for a set of important antibiotics. The next step will be the prudent application of this concept to patients in clinical trials.
Authors
- Christoph Dorn (ORCID: https://orcid.org/0000-0002-2560-9598)
- Alexander Dejaco (ORCID: https://orcid.org/0000-0002-1985-2102)
- Martin G. Kees (ORCID: https://orcid.org/0000-0003-1708-0265)
- Michael Paal (ORCID: https://orcid.org/0000-0001-8831-0238)
- Michael Gruber (ORCID: https://orcid.org/0000-0002-5509-9760)
- Daniel F. Fleischmann (ORCID: https://orcid.org/0000-0002-5493-0620)
- Alexander Kratzer
- Katharina Habler (ORCID: https://orcid.org/0000-0002-5110-346X)
- Constantin Lier
- J Rosenberger
Institutions
- LMU Klinikum (DE)
- University Hospital Regensburg (DE)
- University of Regensburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s40635-024-00696-7
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitätsklinikum Regensburg