Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design
Heritability is found for glial fibrillary acidic protein (60%), neurofilament light chain (42%), and amyloid beta (Aβ) 42/40 (16%) plasma levels. Aβ42/40 plasma levels are sensitive to person-specific environmental influences.
Authors
- David H. Wilson (ORCID: https://orcid.org/0000-0001-8322-0380)
- Lynn Boonkamp (ORCID: https://orcid.org/0000-0002-2200-0832)
- Rebecca Z. Rousset (ORCID: https://orcid.org/0000-0001-9355-7286)
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Inge M.W. Verberk (ORCID: https://orcid.org/0000-0003-0341-7445)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Eco J. C. de Geus (ORCID: https://orcid.org/0000-0001-6022-2666)
- Lannie Ligthart (ORCID: https://orcid.org/0000-0002-6570-3319)
Institutions
- Amsterdam Neuroscience (NL)
- Quanterix (United States) (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1002/alz.14269
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- National Multiple Sclerosis Society
- Alzheimer's Association
- EU Joint Programme – Neurodegenerative Disease Research
- International Progressive MS Alliance
- Multiple Sclerosis Society
- European Commission
- ZonMw
- Vrije Universiteit Amsterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland
- FP7 Health