Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease
LC FDG-PET signal is lower in Alzheimer's disease (AD) patients. LC FDG-PET signal is higher in the preclinical stage of AD. We observed less memory decline in those with higher LC FDG-PET signal. Higher LC FDG-PET signal conferred cognitive resilience in preclinical AD.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- J. Alex Becker (ORCID: https://orcid.org/0000-0001-7435-1338)
- Prokopis C. Prokopiou (ORCID: https://orcid.org/0000-0002-5444-8359)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-4685-5173)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Joyita Dutta (ORCID: https://orcid.org/0000-0002-6712-4927)
- Elouise A. Koops (ORCID: https://orcid.org/0000-0002-4105-4254)
- Julie C. Price
- Maxime Van Egroo (ORCID: https://orcid.org/0000-0002-3142-2623)
- Steven Edward Arnold (ORCID: https://orcid.org/0000-0002-9487-415X)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Massachusetts Amherst (US)
- Maastricht University (NL)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1002/alz.14385
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Massachusetts General Hospital
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Centre d'Imagerie BioMédicale
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
- Canadian Institutes of Health Research
- National Institute of Biomedical Imaging and Bioengineering