Serum-Derived Exosomal TBX2-AS1 Exacerbates COPD by Altering the M1/M2 Ratio of Macrophages through Regulating the miR-423-5p/miR-23b-3p Axis

COPD serum exosomes deliver TBX2-AS1 to macrophages, regulate the miR-423-5p-CELSR2/miR-23b-3p-NEK6 pathway, affect macrophage polarization, and exacerbate the progression of COPD, providing new directions and potential targets for the diagnosis and treatment of COPD.

Authors

Yijun Zhou (ORCID: https://orcid.org/0000-0002-0585-2689)
Fengpeng An (ORCID: https://orcid.org/0000-0002-8359-7804)
YePing Min
Yiming Jiang (ORCID: https://orcid.org/0000-0001-5963-2932)
Tijun Gu
Rong Zhang (ORCID: https://orcid.org/0000-0003-0006-3303)
Qing Luo
JinHai Wang

Institutions

Tibet Autonomous Region People's Hospital (CN)
Changzhou No.2 People's Hospital (CN)
Nanjing Medical University (CN)

Publication Details

Journal: Immunological Investigations
Published: 2024-11-26
DOI: https://doi.org/10.1080/08820139.2024.2434692
Citations: 2
Primary Topic: Extracellular vesicles in disease
Type: article
Field-Weighted Citation Impact: 0.47

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article

Serum-Derived Exosomal TBX2-AS1 Exacerbates COPD by Altering the M1/M2 Ratio of Macrophages through Regulating the miR-423-5p/miR-23b-3p Axis

Yijun Zhou, Fengpeng An, YePing Min, Yiming Jiang et al.

Nov 26, 2024

2 citations

Immunological Investigations

Extracellular vesicles in disease

0.47

article

Serum-Derived Exosomal TBX2-AS1 Exacerbates COPD by Altering the M1/M2 Ratio of Macrophages through Regulating the miR-423-5p/miR-23b-3p Axis

Yijun Zhou, Fengpeng An, YePing Min, Yiming Jiang, Tijun Gu, Rong Zhang, Qing Luo, JinHai Wang

November 26, 2024article en

2 citations

Abstract

COPD serum exosomes deliver TBX2-AS1 to macrophages, regulate the miR-423-5p-CELSR2/miR-23b-3p-NEK6 pathway, affect macrophage polarization, and exacerbate the progression of COPD, providing new directions and potential targets for the diagnosis and treatment of COPD.

Immunological InvestigationsVol. 54(2)

Tibet Autonomous Region People's Hospital (CN), Changzhou No.2 People's Hospital (CN), Nanjing Medical University (CN)

Zero hunger

Openalex Percentile: Top 34%

Extracellular vesicles in disease

0.47

DOI Source OpenAlex

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Serum-Derived Exosomal TBX2-AS1 Exacerbates COPD by Altering the M1/M2 Ratio of Macrophages through Regulating the miR-423-5p/miR-23b-3p Axis — Yijun Zhou, Fengpeng An, et al. · Immunological Investigations (2024) | TGRS Research Map | TGRS