Antifungal and anti-biofilm effects of hydrazone derivatives on <i>Candida</i> spp

Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of <i>Candida</i>. In this context, the development of innovative antifungal drugs is urgently needed. During invasive candidiasis, yeast is submitted to many stresses (oxidative, thermic, osmotic) in the human host. In order to resist in this context, yeast develops different strategy, especially the biosynthesis of trehalose. Starting from the 3D structural data of TPS2, an enzyme implicated in trehalose biosynthesis, we identified hydrazone as an interesting scaffold to design new antifungal drugs. Interestingly, our hydrazone derivatives which demonstrate antifungal and anti-biofilm effects on <i>Candida spp</i>., are non-toxic in <i>in vitro</i> and <i>in vivo</i> models (<i>Galleria mellonella</i>).

Authors

Institutions

Publication Details

Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Published
2024-11-26
DOI
https://doi.org/10.1080/14756366.2024.2429109
Citations
2
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.78

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp

Clovis Bortolus, Faustine Dubar, Laure Kamus, Alina Ghinet et al.
2 citations
Journal of Enzyme Inhibition and Medicinal Chemistry
Antifungal resistance and susceptibility
0.78
article

Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp

Clovis Bortolus, Faustine Dubar, Laure Kamus, Alina Ghinet, Marc F. Lensink, Jérôme de Ruyck, Boualem Sendid, Pierre Popczyk
article en
2 citations

Abstract

Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of <i>Candida</i>. In this context, the development of innovative antifungal drugs is urgently needed. During invasive candidiasis, yeast is submitted to many stresses (oxidative, thermic, osmotic) in the human host. In order to resist in this context, yeast develops different strategy, especially the biosynthesis of trehalose. Starting from the 3D structural data of TPS2, an enzyme implicated in trehalose biosynthesis, we identified hydrazone as an interesting scaffold to design new antifungal drugs. Interestingly, our hydrazone derivatives which demonstrate antifungal and anti-biofilm effects on <i>Candida spp</i>., are non-toxic in <i>in vitro</i> and <i>in vivo</i> models (<i>Galleria mellonella</i>).

Journal of Enzyme Inhibition and Medicinal ChemistryVol. 39(1)
Centre National de la Recherche Scientifique (FR), Alexandru Ioan Cuza University (RO), Inserm (FR), Université de Lille (FR), Institut Pasteur de Lille (FR), Centre Hospitalier Universitaire de Lille (FR), Centre Hospitalier Universitaire de La Réunion (RE), Unité de Glycobiologie Structurale et Fonctionnelle (FR), Processus Infectieux en Milieu Insulaire Tropical (RE), Institut de Recherche pour le Développement (FR)
Université de Lille, Institut National de la Santé et de la Recherche Médicale, Région Hauts-de-France, Société d'Accélération du Transfert de Technologies
Zero hunger
Openalex Percentile: Top 26%
Antifungal resistance and susceptibility
0.78
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.