Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy
Our studies used a structure-based approach to investigate α-synuclein misfolding, resulting in the creation of a powerful panel of cell lines that can be used to interrogate MSA strain biology.
Authors
- Sara A. M. Holec (ORCID: https://orcid.org/0000-0003-0800-1115)
- Chimere Ezeiruaku
- Christine Brown
- Amanda L. Woerman (ORCID: https://orcid.org/0000-0003-4029-1968)
- Steven H. Olson (ORCID: https://orcid.org/0000-0001-9615-9355)
- Matthew P. Frost
- Patrícia Reis
- Samantha L Liu (ORCID: https://orcid.org/0009-0007-3692-0879)
Institutions
- Dartmouth College (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- University of Massachusetts Amherst (US)
- Discovery Institute (US)
- UConn Health (US)
- Colorado State University (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3233/jpd-240296
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Neuroscience Research Australia
- University of New South Wales
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke