The way to effective prevention of cardiovascular complications: review

A descriptive review of modern Russian and foreign literature devoted to the polypill concept in internal medicine and cardiology practice is presented. Methodology . The following databases were used in the search for information: PubMed, Scopus, Web of Science and Cochrane Library, as well as Russian databases, including eLIBRARY and CyberLeninka. The search used keywords and phrases such as "polypill", "combination the­rapy", "cardiovascular diseases", "adherence", "polycomponent drugs" and their analogues in English and Russian. Particular attention was paid to studies published over the past 15 years, with an emphasis on studies conducted over the past 5 years to reflect current trends and innovations in the use of polypills. Results . Clinical evidence of the benefits of fixed-dose combinations al­lows the implementation of the polypill strategy in practice and to achieve maximum reduction of cardiovascular risk. Conclusion . Novel drug combinations have already been developed and are available for use. They need to be introduced so that the therapy is most adapted for many patients and effective in achieving different therapeutic goals in internal medicine and cardiology practice.