Compound D from Zingiber cassumunar Roxb. attenuated type 2 inflammatory cytokine-induced tight junction disruption in airway epithelial cells
Compound D can suppress IL-4/IL-13-induced epithelial inflammation and TJ disruption through STAT6 inhibition. The agent is a promising candidate for therapeutic or adjunctive treatment of type 2 inflammation-associated diseases, including asthma.
Authors
- Phuntila Tharabenjasin (ORCID: https://orcid.org/0000-0002-4191-2802)
- Thaweephol Dechatiwongse Na Ayudhya
- Pasistha Termworasin
- Orapan Poachanukoon (ORCID: https://orcid.org/0000-0003-0610-8242)
- Aekkacha Moonwiriyakit (ORCID: https://orcid.org/0000-0001-8946-8694)
Institutions
- Thammasat University (TH)
- Mahidol University (TH)
- Ramathibodi Hospital (TH)
Publication Details
- Journal
- Asian Pacific Journal of Allergy and Immunology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.12932/ap-180624-1873
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mahidol University
- Thammasat University