Pharmacodynamics of the S1P<sub>1</sub> receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

This study further characterised the mechanism of action of cenerimod in patients with SLE and substantiated the scientific rationale for cenerimod 4 mg in the phase 3 clinical trials in moderate to severe SLE (OPUS-1/-2).

Authors

Peter Cornelisse
Madeleine Suffiotti
Daniel S. Strasser (ORCID: https://orcid.org/0000-0002-0097-1937)
Mark Murphy (ORCID: https://orcid.org/0000-0002-9735-7887)
Marcel P. Keller (ORCID: https://orcid.org/0000-0002-9692-662X)
Ouali Berkani
Pijus Brazauskas
Gustavo Seifer

Institutions

Idorsia (Switzerland) (CH)
Tris Pharma (United States) (US)

Publication Details

Journal: PubMed
Published: 2024-11-24
DOI: https://doi.org/10.1136/ard-2024-226547
Citations: 2
Primary Topic: Mast cells and histamine
Type: article
Field-Weighted Citation Impact: 0.48

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article

Pharmacodynamics of the S1P₁ receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Peter Cornelisse, Madeleine Suffiotti, Daniel S. Strasser, Mark Murphy et al.

Nov 24, 2024

2 citations

PubMed

Mast cells and histamine

0.48

article

Pharmacodynamics of the S1P₁ receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Peter Cornelisse, Madeleine Suffiotti, Daniel S. Strasser, Mark Murphy, Marcel P. Keller, Ouali Berkani, Pijus Brazauskas, Gustavo Seifer

November 24, 2024article en

2 citations

Abstract

This study further characterised the mechanism of action of cenerimod in patients with SLE and substantiated the scientific rationale for cenerimod 4 mg in the phase 3 clinical trials in moderate to severe SLE (OPUS-1/-2).

PubMedVol. 84(2)

Idorsia (Switzerland) (CH), Tris Pharma (United States) (US)

Openalex Percentile: Top 33%

Mast cells and histamine

0.48

DOI Source OpenAlex

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