Protective effects of sumatriptan against optic nerve injury in rats via modulation of kynurenine pathway, oxidative stress and apoptosis
These findings suggest that sumatriptan can enhance retinal cell viability, improve optic nerve function, and decrease inflammation, possibly through attenuation of TLR4, ERK, and kynurenine signaling pathways. Thus, future clinical trials should assess the efficacy of low-dose intravitreal sumatriptan for patients with TON.
Authors
- Amir Shadboorestan (ORCID: https://orcid.org/0000-0002-5695-8934)
- Masoud Aghsaei Fard (ORCID: https://orcid.org/0000-0003-4005-2967)
- Razieh Mohammad Jafari (ORCID: https://orcid.org/0000-0001-7082-0838)
- Sepideh Goudarzi (ORCID: https://orcid.org/0000-0001-8545-8560)
- Ahmad Reza Dehpour (ORCID: https://orcid.org/0000-0002-8001-5565)
- Mehdi Sanatkar (ORCID: https://orcid.org/0000-0002-1871-6854)
- Moein Ala (ORCID: https://orcid.org/0000-0001-5951-4864)
- Leila Aghajanpour
Institutions
- Tarbiat Modares University (IR)
- University of Tehran (IR)
- Farabi Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Bioimpacts
- Published
- 2024-08-20
- DOI
- https://doi.org/10.34172/bi.30409
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tehran University of Medical Sciences and Health Services
- National Institute for Medical Research Development