Study of Spectrum and Outcomes of Acute Febrile Illness Due to Tropical Infections with Thrombocytopenia Causing Acute Kidney Injury at a Tertiary Care Centre - An Observational Study

This research delves into the intricate spectrum of outcomes observed in individuals experiencing acute febrile illness due to tropical infections with concurrent thrombocytopenia, with a particular emphasis on the associated complication of acute kidney injury (AKI). By examining a range of cases, we aim to elucidate the diverse clinical presentations, severity levels, and potential prognostic indicators. Factors such as the underlying etiology, timely intervention, and patient - specific characteristics will be scrutinized to provide a comprehensive understanding of the interplay between tropical fever, thrombocytopenia, and AKI. This exploration seeks to contribute valuable insights for clinicians managing such complex scenarios. Objective: To assess the spectrum and outcomes of acute febrile illness due to tropical infections with thrombocytopenia causing acute kidney injury. Methodology: Between 2022 and 2023, a prospective observational study including 100 patients was carried out in a tertiary care facility. The patients had acute renal injury as a result of acute febrile illness caused by tropical infections with thrombocytopenia. A thorough history was obtained, and a proforma examination was performed. The patient with a positive fever profile panel underwent evaluation for thrombocytopenia and acute renal damage. All research subjects underwent investigations, and additional causes of AKI and thrombocytopenia, such as sepsis, UTIs, obstructive uropathy, and autoimmune disorders, were ruled out. Discharge creatinine value, a predictive indicator of AKI leading to chronic renal injury, was used to compute eGFR. Results: Of the patients in the age groups of 41?50 and 51?60 years (each 29%), men made up the majority (66%) of the patient population. The majority of patients (100%) and evidence of pallor (23%) had feverish symptoms when they first arrived, with malaria accounting for 37% of the cases. The majority of patients (92%) made a full recovery of their renal function (89%). The non - survivors had considerably higher mean levels of urea, creatinine, sodium, and potassium than the survivors (all p - values < 0.0001, p - value = 0.028, respectively). The majority of patients (85%) had conservative care, and a higher percentage of non - survivors needed hemodialysis (p - value < 0.0001).