Canonical amplifications and <i>CDKN2A/B</i> loss refine <i>IDH1/2</i>-mutant astrocytoma prognosis
Combining CDKN2A/B hemizygous-loss and focal gene amplifications reveals a group of IDHmut-astrocytoma patients with an intermediate prognosis, refining IDHmut-astrocytoma classification.
Authors
- L. Nicolas Gonzalez Castro (ORCID: https://orcid.org/0000-0001-7699-5188)
- Keith L. Ligon (ORCID: https://orcid.org/0000-0002-7733-600X)
- Hia S. Ghosh
- Patrick Y. Wen (ORCID: https://orcid.org/0000-0002-0774-7700)
- David M. Meredith (ORCID: https://orcid.org/0000-0002-7054-8624)
- Wenya Linda Bi (ORCID: https://orcid.org/0000-0002-4635-0247)
- Ruchit V. Patel (ORCID: https://orcid.org/0000-0002-3200-4810)
- Elizabeth B. Claus (ORCID: https://orcid.org/0000-0001-9867-8124)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Yale University (US)
- Center for Neuro-Oncology (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1093/neuonc/noae258
- Citations
- 11
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.82