Photo Energy Transfer-Enabled Thiosulfinylation of Alkynes for Asymmetric Synthesis of Sultims
An asymmetric and highly practical thiosulfinylation of alkynes is established for the synthesis of sultim derivatives. The disclosed platform featured broad substrate scope and group tolerance for diverse biologically important molecules under mild and operationally simple conditions. Notably, the obtained chiral sulfinyl derivatives have demonstrated their potential application in further gram-scale synthesis and product derivatizations, providing a chance for drug discovery.
Authors
- Yuxi Wang (ORCID: https://orcid.org/0009-0000-2771-452X)
- Jiang Duan (ORCID: https://orcid.org/0000-0001-6608-5674)
- Chao Shu (ORCID: https://orcid.org/0000-0002-4722-2714)
- Xinke Ouyang
- Zhiming Zhu (ORCID: https://orcid.org/0000-0001-6978-4155)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0003-4264-7665)
- Ziyang Li (ORCID: https://orcid.org/0009-0008-8600-8420)
- Bingyao Shi
- C. Nguyen Xuan
Institutions
- Central China Normal University (CN)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1021/acs.orglett.4c03847
- Citations
- 6
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Central China Normal University
- Wuhan Municipal Science and Technology Bureau
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities